官怡君 Yi-Chun Kuan

Dr Yi-Chun Kuan, MD, is a neurologist and Professor of Neurology at Taipei Medical University, Director of the Neurodegeneration Department at the Taipei Neuroscience Institute, and a PhD student in Biomedical Engineering at National Taiwan University. Her research integrates cognitive neurology, sleep medicine, and human movement science to investigate early mechanisms of cognitive impairment. She leads government-funded studies on sleep-disordered breathing, slow-wave sleep physiology, motion-capture biomechanics, and neuromodulation in mild cognitive impairment and early Alzheimer’s disease. Her work focuses on identifying early biomarkers, characterising cognitive–motor interactions, and developing translational approaches for dementia detection and intervention. 

•  Attending physician, Department of Neurology, Taipei Medical University – Shuang Ho Hospital, Taiwan
• Aug. 2018~present: Deputy Director of Teaching, Center for Evidence Health Care, Shuang-Ho Hospital, Taipei Medical University
• Feb. 2019~present: Researcher, Cochrane Taiwan
• Aug. 2018~present: Recommended physician for dementia diagnosis and treatment in Taiwan
• Dec. 2023~present: Director of Neurodegeneration Department, Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan
• Nov. 2024~present: Chair of the Education Committee, Taiwan Dementia Society
• Feb. 2025~present: Professor, Department of Neurology, School of Medicine, Taipei Medical University, Taiwan 

• 2012 Honorable Award of Research Paper, Taiwan Epilepsy Society 
• 2012 Young Scholars Award of International Conference, Taiwan Epilepsy Society
• 2016 Young Scholars Award of International Conference, Taiwan Epilepsy Society
• 2019 Excellent Literature Verification Award, Taiwan Evidence-Based Medicine Association (TEBMA)
• 2020 Gold Award of Excellent Poster, Taiwan Neurological Society 
• 2021 Silver Award of Oral Presentation, Asian Oceanian Congress of Neurology
• 2022 Third Place of Lecturer of the Year, Shuang Ho Hospital
• 2023 Top 100 Dementia Doctors in Taiwan
• 2024 Oral Presentation Excellence Award, Annual Meeting of Taiwan Neurological Society
• 2024 Poster Award-First Place, Taiwan Dementia Society International Conference
• 2025 Best Paper Award-Third Prize, Taiwan Dementia Society 

1. Chen YY, Chien R, Lin YC, Liu WT, Majumdar A, Chen YL, Kuan YC, Lee KY, Feng PH, Chen KY, Kang JH, Lee HC, Tsai CY. Assessing cardiac function in obstructive sleep apnea using a novel metric: integrating the respiratory event frequency and desaturation duration. BMC Pulm Med. 2025 Nov 12;25(1):520.

2. Lu SH#, Kuan YC(first),# Wu KW, Wang TM, Lu TW. Cognitive-motor dual task induces strategic kinematic adjustments with increased toe-obstacle clearance for older adults during obstacle crossing. PLoS One. 2025 Oct 14;20(10):e0334321.

3. Yang CC, Huang KY, Hsu JL, Hu CJ, Lu YH, Kuan YC(corresponding). Effects of intermittent theta-burst stimulation on cognition and glymphatic system activity in mild cognitive impairment and very mild Alzheimer's disease: a randomized controlled trial. J Neuroeng Rehabil. 2025 Sep 26;22(1):195.

4. Hu CJ, Kuan YC, Yang CC. Reply to the Letter to the Editor: "Comment on 'Cogstate Brief Battery performance in assessing cognitive impairment in Taiwan: A prospective, multi-center study'". J Formos Med Assoc. 2025 Jul 4:S0929-6646(25)00333-X.

5. Lu SH#, Kuan YC(first)#, Wang TM, Wu KW, Lu TW. Effects of Divided Attention on Kinematic Adaptations During Obstacle-Crossing in Mild Cognitive Impairment. Gait & Posture. Available online 30 June 2025. In Press, Journal Pre-proof. 

6. Kuan YC(first)#, Lin HW#, Yang CC, Hsu JL, Liu WT, Hu CJ, Majumdar A, Lin YC, Peng CW, Tsai CY. Slow-wave sleep, oxygen desaturation, and memory consolidation in sleep-disturbed individuals. Int J Clin Health Psychol. 2025 Apr-Jun;25(2):100574.

7. Kuo CF, Lin YC, Chen ZY, Kang JH, Chang CC, Chen Z, Majumdar A, Chen YL, Kuan YC, Lee KY, Feng PH, Chen KY, Lee HC, Cheng WH, Liu WT, Tsai CY. From reactive to proactive: Machine learning models for continuous positive airway pressure adjustments using heart rate variability and oximetry-related parameters. Digit Health. 2025 Apr 28;11:20552076251339273.

8. Huang CH#, Chen CY#, Lin HW, Chiu YF, Lin LF, Tam KW, Lu TW, Chiang SW*, Kuan YC*(corresponding). Effects of Whole-Body Vibration Therapy on Physical Function in Children With Cerebral Palsy: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Phys Ther. 2025 Apr 11:pzaf052. 

9. Kuan YC(first), Jhang KM, Wang WF, Yeh YC, Chen CS, Yang CC, Hu CJ. Cogstate Brief Battery performance in assessing cognitive impairment in Taiwan: A prospective, multi-center study. J Formos Med Assoc. 2025 Feb 20:S0929-6646(25)00067-1. 

10. Peng HH#, Hu CE#, Wu YL, Liu WT, Tsai CY, Kuan YC*(corresponding). Effects of Continuous Positive Airway Pressure on Renal Function in Adults with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis. Sleep Breath. 2025 Feb 13;29(1):102.  

11. Lee KT, Liu WT, Lin YC, Chen Z, Ho YH, Huang YW, Tsai ZL, Hsu CW, Yeh SM, Lin HY, Majumdar A, Chen YL, Kuan YC, Lee KY, Feng PH, Chen KY, Kang JH, Lee HC, Ho SC, Tsai CY. Utilizing a Wireless Radar Framework in Combination With Deep Learning Approaches to Evaluate Obstructive Sleep Apnea Severity in Home-Setting Environments. J Multidiscip Healthc. 2025 Jan 23;18:381-393.

12. Yang FA, Lin CH, Chung HN, Kuan YC, Escorpizo R, Chen HC. Effects of Repetitive Transcranial Magnetic Stimulation on Poststroke Hemineglect: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Neurorehabil Neural Repair. 2024 Dec 27:15459683241309572. 

13. Lin HW, Chen HC, Lin LF, Tam KW, Kuan YC*(corresponding). Laser therapy for Bell's palsy: a systematic review and meta-analysis of randomized trials. Lasers Med Sci. 2024 Nov 15;39(1):282.

14. Lu TW, Lu SH, Yu CH, Wu KW, Kuan YC*(corresponding). A multi-objective optimal control approach to motor control strategy changes in older people with mild cognitive impairment during obstacle crossing. J Neuroeng Rehabil. 2024 Nov 6;21(1):200. 

15. Tsai CY, Su CL, Huang HT, Lin HW, Lin JW, Hei NC, Cheng WH, Chen YL, Majumdar A, Kang JH, Lee KY, Chen Z, Lin YC, Wu CJ, Kuan YC, Lin YT, Hsu CR, Lee HC, Liu WT. Mediating role of obstructive sleep apnea in altering slow-wave activity and elevating Alzheimer's disease risk: Pilot study from a northern Taiwan cohort. Sleep Health. 2024 Oct 16:S2352-7218(24)00188-8. 

16. Wang PH, Lin HW, Nguyen TTT, Hu CJ, Huang LK, Tam KW, Kuan YC*(corresponding). Efficacy of Aromatherapy Against Behavioral and Psychological Disturbances in People With Dementia: A Meta-Analysis of Randomized Controlled Trials. J Am Med Dir Assoc. 2024 Aug 8:105199. 

17. Lin SY, Tsai CY, Majumdar A, Ho YH, Huang YW, Kao CK, Yeh SM, Hsu WH, Kuan YC, Lee KY, Feng PH, Tseng CH, Chen KY, Kang JH, Lee HC, Wu CJ, Liu WT. Combining a wireless radar sleep monitoring device with deep machine learning techniques to assess obstructive sleep apnea severity. J Clin Sleep Med. 2024 Aug 1;20(8):1267-1277. 

18. Cheng YW, Lin YJ, Lin YS, Hong WP, Kuan YC, Wu KY, Hsu JL, Wang PN, Pai MC, Chen CS, Fuh JL, Hu CJ, Chiu MJ. Application of blood-based biomarkers of Alzheimer's disease in clinical practice: Recommendations from Taiwan Dementia Society. J Formos Med Assoc. 2024 Jan 30:S0929-6646(24)00051-

19. Huang HH, Chen CC, Lee HH, Chen HC, Lee TY, Tam KW, Kuan YC*(corresponding). Efficacy of vestibular rehabilitation in vestibular neuritis: a systematic review and meta-analysis. Am J Phys Med Rehabil. 2024 Jan 1;103(1):38-46.

20. Britton GB, Huang LK, Villarreal AE, Levey A, Philippakis A, Hu CJ, Yang CC, Mushi D, Oviedo DC, Rangel G, Ho JS, Thompson L, Khemakhem M, Ross M, Carreira MB, Kim N, Joung P, Albastaki O, Kuo PC, Low S, Paddick SM, Kuan YC, Au R. Digital phenotyping: An equal opportunity approach to reducing disparities in Alzheimer's disease and related dementia research. Alzheimers Dement (Amst). 2023 Nov 29;15(4):e12495. 

21. Tsai CY, Huang HT, Liu M, Cheng WH, Hsu WH, Kuan YC, Majumdar A, Lee KY, Feng PH, Tseng CH, Chen KY, Kang JH, Lee HC, Wu CJ, Liu WT. Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations. Front Public Health. 2023 Jun 15;11:1175203.

22. Kuo CF, Tsai CY, Cheng WH, Hs WH, Majumdar A, Stettler M, Lee KY, Kuan YC, Feng PH, Tseng CH, Chen KY, Kang JH, Lee HC, Wu CJ, Liu WT. Machine learning approaches for predicting sleep arousal response based on heart rate variability, oxygen saturation, and body profiles. Digit Health. 2023 Oct 13;9:20552076231205744. 

23. Huang LK, Kuan YC(co-first), Lin HW, Hu CJ. Clinical trials of new drugs for Alzheimer disease: a 2020-2023 update. J Biomed Sci. 2023 Oct 2;30(1):83. 

24. Chiu PY, Chung CC, Tu YK, Tseng CH, Kuan YC*(corresponding). Therapeutic hypothermia in patients after cardiac arrest: A systematic review and meta-analysis of randomized controlled trials. Am J Emerg Med. 2023 Sep;71:182-189. 

25. Tsai CY, Huang HT, Liu M, Cheng WH, Hsu WH, Kuan YC, Majumdar A, Lee KY, Feng PH, Tseng CH, Chen KY, Kang JH, Lee HC, Wu CJ, Liu WT. Associations between air pollution, intracellular-to-extracellular water distribution, and obstructive sleep apnea manifestations. Front Public Health. 2023 Jun 15;11:1175203. 

26. Tsai CY, Cheong HI, Houghton R, Hsu WH, Lee KY, Kang JH, Kuan YC, Lee HC, Wu CJ, Li LJ, Lin YT, Lin SY, Manole I, Majumdar A, Liu WT. Predicting Fatigue-Associated Aberrant Driving Behaviors Using a Dynamic Weighted Moving Average Model With a Long Short-Term Memory Network Based on Heart Rate Variability. Hum Factors. 2023 Jun 30:187208231183874. 

27. Hsu WH, Yang CC, Tsai CY, Majumdar A, Lee KY, Feng PH, Tseng CH, Chen KY, Kang JH, Lee HC, Wu CJ, Kuan YC*(corresponding), Liu WT*. Association of Low Arousal Threshold Obstructive Sleep Apnea Manifestations with Body Fat and Water Distribution. Life (Basel).2023 May 19;13(5):1218. 

28. Lin HW, Tam KW, Kuan YC*(corresponding). Mindfulness or meditation therapy for Parkinson's disease: A systematic review and meta-analysis of randomized controlled trials. Eur J Neurol. 2023 Aug;30(8):2250-2260. 

29. Tung NT, Lin SY, Liu WT, Kuan YC, Wu CD, Xuan Thao HN, Dung HB, Chung Thuy TP, Chuang HC. Higher Particulate Matter Deposition in Alveolar Region Could Accelerate Body Fat Accumulation in Obstructive Sleep Apnea. ACS Environ Au. 2022 Sep 23;3(1):12-17. 

30. Liu WT, Huang HT, Hung HY, Lin SY, Hsu WH, Lee FY, Kuan YC, Lin YT, Hsu CR, Stettler M, Yang CM, Wang J, Duh PJ, Lee KY, Wu D, Lee HC, Kang JH, Lee SS, Wong HJ, Tsai CY, Majumdar A. Continuous Positive Airway Pressure Reduces Plasma Neurochemical Levels in Patients with OSA: A Pilot Study. Life (Basel). 2023 Feb 22;13(3):613. 

31. Tsai CY, Liu WT, Hsu WH, Majumdar A, Stettler M, Lee KY, Cheng WH, Wu D, Lee HC, Kuan YC, Wu CJ, Lin YC, Ho SC. Screening the risk of obstructive sleep apnea by utilizing supervised learning techniques based on anthropometric features and snoring events. Digit Health. 2023 Mar 6;9:20552076231152751. 

32. Chen TA, Mao ST, Lin HC, Liu WT, Tam KW, Tsai CY, Kuan YC*(corresponding). Effects of inspiratory muscle training on blood-pressure- and sleep-related outcomes in patients with obstructive sleep apnea: A meta-analysis of randomized controlled trials. Sleep and Breathing. 2023 Oct;27(5):1953-1966 

33. Lu SH, Kuan YC(co-first), Wu KW, Lu HY, Tsai YL, Chen HH*, Lu TW*. Kinematic Strategies for Obstacle-Crossing in Older Adults with Mild Cognitive Impairment. Front Aging Neurosci. 2022 Dec 13;14:950411.

34. Tsai CY, Wu SM, Kuan YC, Lin YT, Hsu CR, Hsu WH, Liu YS, Majumdar A, Stettler M, Yang CM, Lee KY, Wu D, Lee HC, Wu CJ, Kang JH, Liu WT. Associations between risk of Alzheimer's disease and obstructive sleep apnea, intermittent hypoxia, and arousal responses: A pilot study. Front Neurol. 2022 Nov 30;13:1038735. 

35. Tsai CY, Huang HT, Cheng HC, Wang J, Duh PJ, Hsu WH, Stettler M, Kuan YC, Lin YT, Hsu CR, Lee KY, Kang JH, Wu D, Lee HC, Wu CJ, Majumdar A, Liu WT. Screening for Obstructive Sleep Apnea Risk by Using Machine Learning Approaches and Anthropometric Features. Sensors (Basel). 2022 Nov 9;22(22):8630. 

36. Tsai CY, Majumdar A, Wang Y, Hsu WH, Kang JH, Lee KY, Tseng CH, Kuan YC, Lee HC, Wu CJ, Houghton R, Cheong HI, Manole I, Lin YT, Joyce Li LY, Liu WT. Machine Learning Model for Aberrant Driving Behaviour Prediction Using Heart Rate Variability: A Pilot Study Involving Highway Bus Drivers. Int J Occup Saf Ergon. 2022 Oct 24:1-35. 

37. Kuan YC(first), Hong CT, Chen PC, Liu WT, Chung CC. Logistic regression and artificial neural network-based simple predicting models for obstructive sleep apnea by age, sex, and body mass index. Math Biosci Eng. 2022 Aug 10;19(11):11409-11421. 

38. Lin YN, Huang SW, Kuan YC, Chen HC, Jian WS, Lin LF. Hybrid robot-assisted gait training for motor function in subacute stroke: a single-blind randomized controlled trial. J Neuroeng Rehabil. 2022 Sep 14;19(1):99. doi: 10.1186/s12984-022-01076-6 

39. Loh MS, Kuan YC, Wu CW, Liao CD, Hong JP, Chen HC. Upper Extremity Contralaterally Controlled Functional Electrical Stimulation Versus Neuromuscular Electrical Stimulation in Post-Stroke Individuals: A Meta-Analysis of Randomized Controlled Trials. Neurorehabil Neural Repair. 2022 Jul;36(7):472-482. 

40. Tung NT, Lin SY, Dung HB, Thuy TPC, Kuan YC, Tsai CY, Lo CC, Lo K, Liu WT, Chuang HC. Associations of overnight changes in body composition with positional obstructive sleep apnea. Sleep Breath. 2022 Jun 25. 

41. Chen JH, Hong CT, Chung CC, Kuan YC*(corresponding), Chan L*. Safety and efficacy of endovascular thrombectomy in acute ischemic stroke treated with anticoagulants: a systematic review and meta-analysis. Thromb J. 2022 Jun 21;20(1):35. 

42. Ou CH, Shiue CC, Kuan YC, Liou TH, Chen HC, Kuo TJ. Neuromuscular Electrical Stimulation of Upper Extremities in Patients with Cerebral Palsy: A systematic review and Meta-Analysis of Randomized Controlled Trials. Am J Phys Med Rehabil. 2023 Feb 1;102(2):151-158. 

43. Chang HY, Li YY, Hong CT*, Kuan YC*(corresponding). Efficacy of rasagiline monotherapy for early Parkinson disease: A systematic review and meta-analysis of randomized controlled trials. J Psychopharmacol. 2022 Jun;36(6):704-714.

44. Chiang SW, Liu HW, Loh EW, Tam KW, Wang JY, Huang WL*, Kuan YC*(corresponding). Whey protein supplementation improves postprandial glycemia in persons with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Nutr Res. 2022 Apr 18;104:44-54. .

45. Tsai CY, Liu YS, Majumdar A, Houghton R, Lin SY, Lin YT, Ho SC, Cheng WH, Liu WT, Wu D, Lee HC, Kuan YC, Hsu WH, Hsu SM, Lo CC, Chiu PC, Chen YR, Lo K, Chen CI, Lai HJ, Chen CY. Association between cyclic variation in the heart rate index and biomarkers of neurodegenerative diseases in obstructive sleep apnea syndrome: A pilot study. J Clin Neurosci. 2022 Apr;98:37-44.

46. Tsai CY, Hsu WH, Lin YT, Liu YS, Lo K, Lin SY, Majumdar A, Cheng WH, Lee KY, Wu D, Lee HC, Hsu SM, Ho SC, Lin FC, Liu WT*, Kuan YC *(corresponding). Associations among sleep-disordered breathing, arousal response, and risk of mild cognitive impairment in a northern Taiwan population. J Clin Sleep Med. 2022 Apr 1;18(4):1003-1012. 

47. Wang HY, Chen YH, Kuan YC, Huang SW, Lin LF, Chen HC. The effectiveness of functional electrical stimulation of the legs in patients with heart failure: A systematic review and meta-analysis of randomized controlled trials. Clin Rehabil. 2022 Mar;36(3):303-316. 

48. Kuan YC(first), Lin LF, Wang CY, Hu CC, Liang PJ, Lee SC. Association Between Turning Mobility and Cognitive Function in Chronic Poststroke. Front Neurol. 2022 Feb 23;13:772377. 

49. Yu YC, Chung CC, Tu YK, Hong CT, Chen KH, Tam KW, Kuan YC*(corresponding). Efficacy and safety of botulinum toxin for treating sialorrhea: A systematic review and meta-analysis. Eur J Neurol. 2022 Jan;29(1):69-80. 

50. Tsai CY, Kuan YC(co-first), Hsu WH, Lin YT, Hsu CR, Lo K, Hsu WH, Majumdar A, Liu YS, Hsu SM, Ho SC, Cheng WH, Lin SY, Lee KY, Wu D, Lee HC, Wu CJ, Liu WT. Differentiation Model for Insomnia Disorder and the Respiratory Arousal Threshold Phenotype in Obstructive Sleep Apnea in the Taiwanese Population Based on Oximetry and Anthropometric Features. Diagnostics. Diagnostics (Basel). 2021 Dec 27;12(1):50. 

51. Liu WT, Lin SY, Tsai CY, Liu YS, Hsu WH, Majumdar A, Lin CM, Lee KY, Wu D, Kuan YC, Lee HC, Wu CJ, Cheng WH, Hsu YS. Comparison of Hospital-Based and Home-Based Obstructive Sleep Apnoea Severity Measurements with a Single-Lead Electrocardiogram Patch. Sensors (Basel). 2021 Dec 3;21(23):8097. 

52. Tung NT, Lee YL, Lin SY, Wu CD, Dung HB, Thuy TPC, Kuan YC, Tsai CY, Lo CC, Lo K, Ho KF, Liu WT, Chuang HC. Associations of ambient air pollution with overnight changes in body composition and sleep-related parameters. Sci Total Environ. 2021 Oct 15;791:148265. 

53. Kuan YC(first), Huang LK, Wang YH, Hu CJ, Tseng IJ, Chen HC, Lin LF. Balance and gait performance in older adults with early-stage cognitive impairment. Eur J Phys Rehabil Med. 2021 Aug;57(4):560-567. 

54. Yeh SW, Lin LF, Chen HC, Huang LK, Hu CJ, Tam KW, Kuan YC*(corresponding), Hong CH. High-intensity functional exercise in older adults with dementia: A systematic review and meta-analysis. Clin Rehabil. 2021 Feb;35(2):169-181. 

55. Yen PH, Kuan YC (first), Tam KW, Chung CC, Hong CT, Huang YH. Efficacy of levetiracetam for migraine prophylaxis: A systematic review and meta-analysis. J Formos Med Assoc. 2020 Aug 27:S0929-6646(20)30394-6. 

56. Yeh SW, Lin LF, Tam KW, Tsai CP, Hong CH*, Kuan YC*(corresponding). Efficacy of Robot-Assisted Gait Training in Multiple Sclerosis: A Systematic Review and Meta-Analysis. Mult Scler Relat Disord. 2020 Mar 3;41:102034. . 

57. Huang LK, Tsai JC, Lee HH, Kuan YC, Lee YT, Lin CP, Chao SP, Hu CJ. Dementia screening for elderly in-patients and its association with nursing care satisfaction-an observational study. Medicine (Baltimore). 2020 Jan;99(2):e18741. 

58. Kuan YC(first)+, Huang KW+, Lin CL, Luo JC, Kao CH. Effects of Aspirin or Clopidogrel on Colorectal Cancer Chemoprevention in Patients with Type 2 Diabetes Mellitus. Cancers (Basel). 2019 Sep 29;11(10). pii: E1468. 

59. Cheng CA, Chiu YW, Wu D, Kuan YC, Chen SN, Tam KW. Effectiveness of Tai Chi on fibromyalgia patients: A meta-analysis of randomized controlled trials. Complement Ther Med. 2019 Oct;46:1-8.

60. Kuan YC(first)+, Huang KW+, Lin CL, Luo JC, Kao CH. Short-Term Proton Pump Inhibitor Use and Hepatic Encephalopathy Risk in Patients with Decompensated Cirrhosis. J Clin Med. 2019 Jul 25;8(8). pii: E1108. 

61. Yeh SW, Hong CH, Shih MC, Tam KW, Huang YH, Kuan YC*(corresponding). Low-level laser therapy for fibromyalgia: A systematic review and meta-analysis. Pain Physician. 2019 May;22(3):241-254.

62. Chi NF, Kuan YC, Huang YH, Chan L, Hu CJ, Liu HY, Chiou HY, Chien LN. Development and validation of risk score to estimate 1-year late poststroke epilepsy risk in ischemic stroke patients. Clin Epidemiol. 2018 Aug 21;10:1001-1011. 

63. Chan CH, Huang HH, Lin CH, Kuan YC, Loh EW, Lan TH. Risk of First Onset Stroke in SSRI-Exposed Adult Subjects: Survival Analysis and Examination of Age and Time Effects. J Clin Psychiatry. 2017 Sep/Oct;78(8):e1006-e1012. doi: 10.4088/JCP.16m11123.

64. Anderson CS, Arima H, Lavados P, Billot L, Hackett ML, Olavarría VV, Muñoz Venturelli P, Brunser A, Peng B, Cui L, Song L, Rogers K, Middleton S, Lim JY, Forshaw D, Lightbody CE, Woodward M, Pontes-Neto O, De Silva HA, Lin RT, Lee TH, Pandian JD, Mead GE, Robinson T, Watkins C; HeadPoST Investigators and Coordinators. Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke. N Engl J Med. 2017 Jun 22;376(25):2437-2447. (as a collaborator).

65. Kuan YC(first), Huang KW, Lin CL, Hu CJ, Kao CH. Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):77-83. 

66. Chen L, Lin CC, Huang TW, Kuan YC, Huang YH, Chen HC, Kao CY, Su CM, Tam KW Effect of acupuncture on aromatase inhibitor-induced arthralgia in patients with breast cancer: A meta-analysis of randomized controlled trials. Breast. 2017 Jun;33:132-138. 

67. Huang KW, Kuan YC, Chi NF, Huang YH, Luo JC, Chien LN. Chronic obstructive pulmonary disease is associated with increased recurrent peptic ulcer bleeding risk. Eur J Intern Med. 2017 Jan;37:75-82.

68. Huang KW, Tam KW, Luo JC, Kuan YC*(corresponding). Efficacy and safety of lamivudine versus entecavir for treating chronic hepatitis B virus-related acute exacerbation and acute-on-chronic liver failure: A systematic review and metaanalysis. Journal of Clinical Gastroenterology. 2017 Jul;51(6):539-547. 

69. Kuan YC(first), Huang KW, Yen DJ, Hu CJ, Lin CL, Kao CH. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers reduced dementia risk in patients with diabetes mellitus and hypertension. Int J Cardiol. 2016 Oct 1;220:462-6. 

70. Huang KW, Kuan YC, Luo JC, Lin CL, Liang JA, Kao CH. Impact of long-term gastric acid suppression on spontaneous bacterial peritonitis in patients with advanced decompensated liver cirrhosis. Eur J Intern Med. 2016 Jul;32:91-5. 

71. Kuan YC(first), Wu D, Huang KW, Chi NF, Hu CJ, Chung CC, Tam KW, Huang YH. Effects of Modafinil and Armodafinil in Patients with Obstructive Sleep Apnea: A Meta-Analysis of Randomized Controlled Trials. Clin Ther. 2016 Apr;38(4):874-88. 

72. Liu HT, Lin YC, Kuan YC, Huang YH, Hou WH, Liou TH, Chen HC. Intranasal corticosteroid therapy in the treatment of obstructive sleep apnea: A meta-analysis of randomized controlled trials. Am J Rhinol Allergy. 2016 May;30(3):215-21.

73. Chou LC, Liou TH, Kuan YC, Huang YH, Chen HC. Autologous Blood Injection for Treatment of Lateral Epicondylosis: A Meta-analysis of Randomized Controlled Trials. Phys Ther Sport. 2016 Mar;18:68-73. 

74. Huang YH, Chi NF, Kuan YC, Chan L, Hu CJ, Chiou HY, Chien LN. Efficacy of phenytoin, valproic acid, carbamazepine and new antiepileptic drugs on control of late-onset post-stroke epilepsy in Taiwan. Eur J Neurol. 2015 Nov;22(11):1459-68. 

75. Huang YH, Chen HC, Huang KW, Chen PC, Hu CJ, Tsai CP, Tam KW, Kuan YC*(corresponding). Intravenous Immunoglobulin for Postpolio Syndrome: A Systematic Review and Meta-analysis. BMC Neurol. 2015 Mar 22;15:39.

76. Lin CH, Chen CJ, Kuan YC, Tseng YC; Compression on iliac vein from distended urinary bladder. J Formos Med Assoc. 2014 Sep;113(9):664-5. 

77. Huang KW, Leu HB, Luo JC, Chan WL, Hou MC, Lin HC, Lee FY, Kuan YC*(corresponding). Different peptic ulcer bleeding risk in chronic kidney disease and end-stage renal disease patients receiving different dialysis. Dig Dis Sci. 2014 Apr;59(4):807-13.

78. Kuan YC(first), Wang KC, Yuan WH, Tsai CP. Tumefactive multiple sclerosis in Taiwan. PLoS One. 2013 Jul 18;8(7):e69919.

79. Kuan YC(first), Shih YH, Chen C, Yu HY, Yiu CH, Lin YY, Kwan SY, Yen DJ. Abdominal auras in patients with mesial temporal sclerosis. Epilepsy Behav. 2012 Nov;25(3):386-90. 

80. Kuan YC(first), Yen DJ, Yiu CH, Lin YY, Kwan SY, Chen C, Chou CC, Yu HY. Treatment-seeking behavior of people with epilepsy in Taiwan: a preliminary study. Epilepsy Behav. 2011 Oct;22(2):308-12. 

Kuan YC(first), Chen CM, Botulism. Clinical Medicine. 2009;63:82-90. 

yckuang2@tmu.edu.tw 

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